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BioGrip® TECHNOLOGY

Novel 3D-printed implants for limb salvage surgery, helping to address the clinical challenges of aseptic loosening and soft tissue attachment

BioGrip® is a first of its kind solution to help address complex challenges in limb salvage surgery:

Aseptic loosening is a leading cause of limb salvage prosthesis failure1

  • Osseointegration has the potential to reduce the risk of aseptic loosening of the prosthesis2
  • Porous collar designs with HA treatments have been shown to provide greater surface area for bone ingrowth and have lower rates of aseptic loosening3

MODULAR BioGrip® COLLARS WITH NANO HA

3D-printed collars with nano HA treatment and pore structure designed to support bone ingrowth

MODULAR BioGrip® COLLARS WITH NANO HA

3D-printed collars with nano HA treatment and pore structure designed to support bone ingrowth

  • Novel nano HA treatment:
    • Accelerates and enhances osseointegration4
    • Nano HA surface is 1,000x smaller than traditional coatings, allowing for bone to anchor directly to the implant surface
    • Hydrophilic surface may promote better adhesion and growth of bone cells5
  • 3D-printed pore structure to support bone ingrowth:
    • Pore size range of 502-758μm6
    • Key studies suggest optimal pore size of 350-600μm to support bone ingrowth7
    • Average porosity of 60%6

Supporting soft tissue ingrowth in proximal tibial replacement

Soft tissue failures are a leading cause of limb salvage prosthesis failure1

  • Fixation and healing of the soft tissue envelope is important for long-term success
  • Proximal tibia prostheses require soft tissue ingrowth and attachment features, specifically for the patellar tendon and gastrocnemius flap

ELEOS™ Proximal Tibial Replacement with BioGrip®

3D-printed proximal tibial implant with pore structure and suture hole pattern to support soft tissue ingrowth

ELEOS™ Proximal Tibial Replacement with BioGrip®

3D-printed proximal tibial implant with pore structure and suture hole pattern to support soft tissue ingrowth

  • Novel pore structure to support soft tissue ingrowth8,9
    • Pore size range of 502-758μm6
    • Average porosity of 60%6
  • Key studies suggest soft tissue ingrowth is more prevalent in pores between 600-1000µm8,9
    • Most commercially available porous designs have an average range of 400-550µm
  • Anatomically aligned suture holes in three-directional planes
    • Provide directional attachment of adjacent soft tissues

Product information

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References

1. Henderson et al. Failure Mode Classification for Tumor Endoprosthesis: Retrospective Review of Five Institutions and a Literature Review. J Bone Joint Surg Am 2011;93:418-429. doi:10.2106/JBJS.J.00834. 2. Mumith, et al. Augmenting the osseointegration of endoprosthesis using laser-sintered porous collars. The Bone and Joint Journal. Vol. 99-B, No. 2, February 2017. 3. Cauthup, et al. Long-Term Survival of Cemented Distal Femoral Endoprostheses with a Hydroxyapatite-Coated Collar. J Bone Joint Surg Am. 2013;95:1569-75. 4. Promimic. Increased Fixation and Integration of Titanium – In vivo studies in a rabbit tibia model. Data on File. https://www.promimic.com/wp-content/uploads/2017/02/Increased-Fixation-and-Integration.pdf. 5. Promimic. Introducing Hydrophilicity to your implant. Data on File. https://www.promimic.com/wp-content/uploads/2017/09/Introducing-Hydrophilicity-to-Your-Implant-spread.pdf. 6. Data on File, Onkos, 2020. 7. Taniguchi, et al. Effect of pore size on bone in-growth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment. Mater Sci Eng C Mater Biol Appl. Vol. 59:690-701. February 2016. 8. Dickey, et al. Pore Size and Morphology Modulate Strength of Soft Tissue In-Growth into Porous Titanium Implants. Poster No. 1865 • 54th Annual Meeting of the Orthopaedic Research Society. 9. Dickey, et al. Pore Size Modulates Strength of Soft-Tissue In-Growth and Growth Factor Expression in Novel Porous Titanium Implants. Poster No.2213 • 55th Annual Meeting of the Orthopaedic Research Society.